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Contrary to the widely reiterated Free Radical Theory of Ageing, Ristow was the first to show that the healthpromoting effects associated with low caloric intake, physical exercise and other lifespanextending interventions like sirtuin signalling are caused by increased formation of reactive oxygen species within the mitochondria, causing a vaccinationlike adaptive response that culminates in increased stress resistance and extended longevity, a process called mitohormesis