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We propose a predisposition to tissue fragility in patients with clEDS, in particular of the gastrointestinal tract and emphasize the importance of counseling with regard to the risk of gastrointestinal complications

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Its removal from Category 1 means it is moving into the PCAC review pipeline for a definitive determination rather than remaining in the indefinite "under evaluation" holding pattern

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However, researchers suggested that in the case of high concentrations of CIL56, which induces non-suppressible necrotic death (Shimada et al., 2016)