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Given that erythrocytes are the major peripheral source of syn, such changes have attracted attention in studies of early PDrelated alterations [136]
In newborns, bilirubin can cross the blood brain barrier and cause neurological issues such as kernicterus or acute bilirubin encephalopathy [29]
Mechanistically, it could be because PI3K activates AKT via downstream molecules, and AKT activates mTOR by phosphorylation
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Thondapu et al
