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In this work, by noting that pre-equilibration of ligand-receptor and ternary complex formation occur faster than the receptor internalization and downregulation, we formulate a minimal kinetic model to offer a semi-quantitative yet predictive understanding of the GPCR desensitization and down-regulation

doi: 10.1002/jps.24482

These mice were bred on pure 129/P2 Ola background
