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Furthermore, if MSG effects occur on hypothalamus and GnRH-producing cells, the serum level of GnRH will be remarkably reduced

Figure 2 3.1 Metabolic effect of KD and -HB In this context, KD can influence tumor cell growth by lowering insulin and insulin-like growth factor-1 (IGF-1) levels, thus reducing one of the most common oncogenic pathways such as PI3K-Akt-mTOR implicated in tumor cell proliferation and tumor growth ( Particularly, KBs produced by KD participate in various cellular processes as signaling molecules, regulate inflammation and OxS

Khera R, Murad MH, Chandar AK, Dulai PS, Wang Z, Prokop LJ, Loomba R, Camilleri M, Singh S (2016) Association of pharmacological treatments for obesity with weight loss and adverse events: a systematic review and Meta-analysis

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