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35, in the keto form of curcumin, the heptadienone linkage between the two methoxyphenol rings contains a highly activated carbon atom

Neuron 56 , 5865 (2007)

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Based on these previous studies, the higher respiratory flux leads to consumption of the membrane potential component of the proton motive force by ATP synthase which leads to the generation of ATP producing a mitochondrial membrane depolarization which can be one of the key factors underlying the protective mechanisms of PQQ under H 2 O 2 exposure