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Important evaluations of biocompatibility, immunogenicity, degradation, and biodistribution in vivo are also provided with a focus on safety in addition to the regulatory impediments to clinical translation
Bigini P, Larini S, et al
Increased membrane permeability and intracellular calcium overload can activate a variety of calcium-dependent enzymes, phospholipase C and protease, which further aggravate nerve cells (37)
doi: 10.3233/jad-2005-7206
L.GoedertM
