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While there may have been various strategies developed over the past few decades for erinacine accumulation, it appeared, however, that only three reports concerning erinacines A and C have been published

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the first joins the amino acids, glutamate and glycine to make gamma-glutamylcysteine (GGC) and the second adds a glycine to make glutathione

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Recent advances in monoclonal antibody therapies targeting A plaques (e.g., donanemab, lecanemab) have shown potential, but they also pose significant risks, such as amyloid-related imaging abnormalities with edema (ARIA-E), highlighting the need for safer and more effective alternatives