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The healthy participant population within the Simcyp simulator was modified to include ~17% intermediate CYP2D6 metabolizers and ~83% extensive CYP2D6 metabolizers based on the urinary log (dextromethorphan/dextrorphan) ratios of the clinical study participants (data not shown)

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Moreover, peptide hydrogels can significantly enhance the proliferative phase by serving as a bioactive scaffold for cell growth (Im et al., 2018[60])

Potthoff MJ, Potts A, He T, Duarte JAG, Taussig R, Mangelsdorf DJ, et al

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