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IGF-1R - mediated cellular signaling is thus part of a complex web of well-recognized downstream molecular cascades and crosstalk between members of the IGF-1R family, other RTKs, adhesion receptors and GPCR-induced signaling

In fact, the modulation mechanisms of GSTs in cancer cells are complex and diverse, including the recently revealed functions in DNA repair, autophagy, and glycolysis

On the other hand, it can also inhibit the expression of ABCB1 and suppress the phosphorylation of ERK1/2, p38 and JNK

Furthermore, transgenic expression of GPX-1 or GPX-4 was sufficient to rescue the fusion phenotype in gpx-5 mutants (Fig

.,LiuLWeiWPharmacological mechanisms and therapeutic potential of resveratrol in rheumatoid arthritis.2025;19:61116123
