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The result is a vicious cycle where declining NAD+ leads to worse metabolic function, which can lead to weight gain, which increases NNMT activity further
Any stack involving multiple experimental compounds increases the unknowns around safety and interactions

The other mimics gut hormones that control hunger and insulin

People with a history of alcoholism, anaemia, or gastrointestinal conditions such as Crohns disease and IBS are also more vulnerable

Some patients experience fatigue followed by gradual improvement as their body responds to treatment
