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Studies have shown that obesity induces increased M1 macrophages (M1) polarization in mice, which may further promote iron deposition, according to in vitro studies (63)
It is often advisable to start with a lower dose (e.g., one capsule daily) and gradually titrate up to the full dose as tolerated
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Grigoleit et al
10.1016/j.ccell.2021.07.006 [DOI] [PMC free article] [PubMed] [Google Scholar] 18.Glasheen, M
