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More studies have found that long-term excessive drinking can increase the risk of liver cirrhosis complicated with primary liver cancer, especially after hepatitis B virus attacks the human liver, alcohol will cause increased liver burden, resulting in liver damage, and ultimately accelerate the occurrence and development of liver cancer

10.3892/ijo.2023.5474 43 WangR.SunM.WuG.WangZ.LiuF.XieT.et al

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This observation indicates that ADH5 is epistatic to GCLM in the FA viability assay performed in HCT116 cells, although this phenotype might also be a consequence of partial GSH depletion in GCLM cells compared to the full GSH depletion achieved by L-BSO (Supplementary Fig