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1 Introduction Heart failure (HF) is one of the most prevalent cardiovascular diseases worldwide and poses a significant threat to human health (Zannad, 2018)

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The study proposed that in order to substantially prolong the storage duration and boost the antioxidant capabilities of shiitake mushrooms, they should be subjected to ozone treatment for 30 min every 5 days applying a dosage of 3.2 mg per cubic meter (3.2 mg/m 3 )

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If MTHFR activity is reduced or if intake of folic acid is very high-unmetabolized folic acid (UMFA) can appear in the blood