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Here, we report the rational design of dual-drug-conjugated human serum albumin nanoparticles (ATRA-ATO-NPs) that enable dual-site, spatiotemporal, and simultaneous inhibition of Pin1

Methods Plasma levels of PGA, kynurenine, and tryptophan were quantified by liquid chromatography-mass spectrometry in cohorts comprising healthy TTR wild-type controls, asymptomatic carriers of the TTR-V30M mutation, and symptomatic patients with TTR-V30M amyloidosis

Negative correlation between antioxidant glutathione and pH value in the brain is an early sign of the disease

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