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CNF was stored in an amber color vials until further analysis
Studies have shown that IL-2 exerts anti-inflammatory effects and maintains immune tolerance by regulating the balance of Th17/Treg and Tfh/Tfr, and is a potential treatment for RA (Wu et al., 2020)

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The authors thank the following persons for their contributions to this work: Dolores Otero-Criado, Carlos Carvajales Fernndez, Rosa Zurdo-Baz and Raisa Gonzlez-Prez

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