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Cyanocobalamin Pharmacokinetics European Journal of Cardiovascular Medicine: Vitamin B12 Deficiency in Long-Term Metformin Users USFDA Adverse Event Reporting System: Vitamin B12 Deficiency Associated with Metformin and PPIs MedRxiv (PNAS Preprint): Patient-Reported Treatment Outcomes in ME/CFS and Long COVID Journal of Neurological Sciences / Nutrients: Cognitive Function and Neuropathy

Relative telomere length assay Relative telomere length was determined using real-time quantitative PCR according to Cawthon et al.s protocol 51 , where the relative telomere to single copy gene (T/S) ratios was determined using a standard curve

Glutathione (GSH), composed of gamma-glutamylcysteinylglycine, stands as the most abundant intracellular thiol in aerobic cells, and its synthesis by GSS is essential for diverse cellular processes

Total RNA was treated with DNase I (Sigma-Aldrich), quantified, and reverse transcribed into cDNA using the ReverTra Ace- First Strand cDNA Synthesis Kit (TOYOBO, Osaka, Japan)