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Research has shown that the activation of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) sets in motion events that cause inflammation, abnormalities in the extracellular matrix, tubular atrophy, and fibrosis (84, 189191)

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Role of pancreatic lipase inhibition in obesity treatment: mechanisms and challenges towards current insights and future directions

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IL-8 has been identified as a transcriptional target for KRAS-mediated ERK or PI3K signal transduction, affecting endothelial cell recruitment, tumour-associated inflammation formation, and tumour angiogenesis 90,91