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AP1 is a complex of several proteins including JUN, which is upregulated in motor neurons derived from SOD1 patients compared to other neurons, providing potential mechanistic insights into the selective degeneration of motor neurons in ALS (Bhinge et al., 2005)

ROS is a known inducer of cell proliferation (73)

PMID: 15851010

Comparison of different criteria for interpretation of immunoglobulin G immunoblotting results for diagnosis of Helicobacter pylori infection

MDSUPDRS motor scores and data on dopaminergic treatment were not available for the subjects covered for the transcriptomics profiling, and therefore the comparison of metabolomics and transcriptomics data focused on the case-control analyses and shared network alterations, confirming the treatment-independence using the metabolomics data (see section on Pathway and network analyses below)