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Encapsulating drugs across the ion gradient boosts trapping efficiency and reduces drug efflux from vesicles by 30-fold [147]
In the heart, the metabolome is characterized by amino acid depletion, evidence of altered redox balance including glutathione depletion, and a shift from oxidative phosphorylation to alternative energy production pathways
Research findings from full-length T4 studies cannot be assumed to apply directly to the fragment
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The subsequent oxidative damage includes mitochondrial DNA (mtDNA) injury, opening of the permeability transition pore (mPTP), and initiation of apoptotic pathways [100]
