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Severe selenium deficiency can lead to the occurrence of diseases such as Keshan disease, KaschinBeck disease, and White Muscle Disease [13,14,15,16]

McLaughlin LA, Niazi U, Bibby J, David JP, Vontas J, Hemingway J, Ranson H, Sutcliffe MJ, Paine MJ: Characterization of inhibitors and substrates ofAnopheles gambiaeCYP6Z2.Insect Mol Biol2008, 17(2):125-135

A study observed that exogenous glutamine can synthesize nucleotides in human primary cancer samples cultured in vitro [78]
Proteomic discovery of chemical probes that perturb protein complexes in human cells

The appearance is consistent across patient ages, though older patients tend to experience it more dramatically because they have less collagen reserve and less skin elasticity to compensate for the structural changes
