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The first category includes pain management medications: gabapentin, pregabalin, duloxetine, tricyclic antidepressants, and topical lidocaine or capsaicin

Some TCM herbs contain toxic components such as aconitine in Aconitum species, which can cause severe poisoning if improperly processed or overdosed

Furthermore, p62, also known as sequestosome-1 (SQSTM1), is a multifunctional adaptor protein essential for autophagy, cellular signaling, and protein degradation

Bioavailability: Numerous phytochemicals exhibit limited bioavailability, implying they are inadequately absorbed and processed within the body, thereby constraining their capacity to reach the damaged brain tissue effectively

Degranulation products, such as histamine, cytokines, chemokines, proteases, and nitric-oxide, have further immune and defensive roles