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Hypoxia and defective apoptosis drive genomic instability and tumorigenesis
doi: 10.1016/j.canlet.2019.08.007 17 WangWXieYMalhotraA

For instance, manifestation of radiation toxicity at the cellular level involves simultaneous activation of various pro-survival and cytotoxic pathways in a ROS-dependent (indirect effect of radiation) and independent (direct effect of radiation) manner [37, 40, 100]

One of those circuits handles detoxification

Glaubitz C
