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However, these treatments often rely on enema or oral administration, which generally suffers from limited rectal retention time, insufficient local drug exposure, or low systemic bioavailability, thus limiting efficacy stability and patient compliance [7, 9]

Quorum sensing is one of the most important mechanisms that govern bacterial biofilm resistance against antibiotics, while the fimH gene plays a crucial role in bacterial virulence by contributing the fimbriae production

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In addition to essential nutrients, mushrooms have several bioactive compounds, including polysaccharides, lectins, terpenoids, sterols, and alkaloids, among others, which may positively impact health [9]

BUON 17 , 658662 (2012)