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More recently, a breakthrough 2026 study utilizing both in-vitro cellular models and an in-vivo human pharmacokinetic trial further solidified these findings

An inappropriate diet can exacerbate renal excretion and elevate the risk of cardiovascular disease in individuals with diabetes [93]

Novel formulations such as lipid nanoparticles, esterified derivatives, or intranasal carriers should be systematically compared for pharmacokinetics, bloodbrain barrier penetration, and clinical efficacy

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All solvents were of UHPLC grade (Honeywell)