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10.1097/qad.0000000000001222 [DOI] [PMC free article] [PubMed] [Google Scholar] Hamanishi T., Furuta H., Kato H., Doi A., Tamai M., Shimomura H., et al

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Cereblon-based PROTACs: factors influencing efficacy The efficacy of cereblon-based PROTACs depends directly on the absence of mutations that interfere with the binding of the degrader to the protein, or indirectly, on mutations that interfere with the formation of the E3 ubiquitin ligase CRL4 CRBN complex, such as mutations that interfere with the binding between cereblon and the DDB1 protein