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Chemoprotectants are natural or synthetic chemical compounds that can ameliorate, mimic, or inhibit the toxic or adverse effects of structurally different chemotherapeutic agents, radiation therapy, cytotoxic drugs, or naturally occurring toxins, without compromising the anticancer or antitumor potential of the chemotherapeutic drugs [80]

The profound function of H 2 0 2 is illustrated by catalase, which restores the spontaneous induction of tyrosine phosphorylation in capacitating mammalian spermatozoa, and hence, reduces functions, such as hyperactivation, acrosomal exocytosis, and sperm-egg fusion

For instance, the oxidoreductase ferroptosis suppressor protein 1 (FSP1, also called AIFM2) reduces ubiquinone (also called coenzyme Q or CoQ) to ubiquinol (CoQH 2 ) at the plasma membrane

Similarly, another randomized study by Ghorbani et al