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For shRNA-based silencing of CBP, we transfected PC12-ND6 cells with the pRFP-C-RS ratSH shRNA turboRFP vectors (Origene, Rockville, MD containing either the scrambled negative control shRNA cassette (Cat # TR30015) or the rat CBP targeting shRNA FI750477 (AAGACTGTGGAGGTCAAGCCAGGAATGAA) (Cat# TF712619)

doi: 10.1016/S0140-6736(19)30427-1 4 ReijmerYDLeemansABrundelMKappelleLJBiesselsGJUtrecht Vascular Cognitive Impairment Study Group

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Some patients may experience mild symptoms, while others may be asymptomatic, but about 5% of cases go on to develop ARDS

Relationship between the Soluble Glutathione-dependent delta 5-3-ketosteroid Isomerase and the Glutathione S-Transferases of the Liver