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The World Alzheimer Report of 2015 underlined that over forty-six million individuals across the globe have dementia, with the number expected to rise to over seventy-four million by 2030 and a further increase to over a hundred and thirty-one million individuals by 2050 [1]

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Another important culprit in PD is the activation of platelet and coagulation system induced by the trauma of tunica albuginea (Gonzalez-Cadavid and Rajfer, 2005)