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3.1.1 Topoisomerase inhibitors Topoisomerase inhibitors are a class of anticancer drugs whose mechanism of action is based on blocking topoisomerase enzymes from re-ligating the DNA strands after supercoiling, thus preventing DNA replication [61]

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Aside from the effect on immunoglobulin content, there was also a significant improvement in cytokines like IFN-gamma and IL4 and in CD45+, CD3+, CD4+, CD8+ and CD19+, as well as in natural killer (NK) cells

Case example : A patient receives collection of capillary blood specimen (e.g., finger, heel or ear stick)

Diabetes triggers a PARP1 mediated death pathway in the heart through participation of FoxO1