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For example, senescent astrocytes show upregulated expression of IL-6, IL-8, IL-1, MMP3, MMP10, and TIMP2, while neuroprotective factors such as IL-10, NGF (nerve growth factor), and BDNF (brain-derived neurotrophic factor) are downregulated (Lye et al., 2019)

Evidence suggests that NAPQI is capable of binding to several cellular proteins, particularly mitochondrial proteins [44]

The potential mechanisms such as enhanced tissue repair, angiogenesis, and anti-inflammatory effects certainly warrant further exploration in human medicine

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