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Administration of the agonists CBD (TRPV2), GSK1702934A (TRPC3) and Yoda1 (Piezo1) immediately triggered strong, moderate and mild Ca 2+ influx, respectively, with comparable responses observed in WT and XKR8 KO BMNs, but probenecid (TRPV2) and GSK1016790A (TRPV4) did not (Extended Data Fig

The pain can range from tingling and numbness to sharp, stabbing sensations and may exhibit temperature variations such as burning or cold

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4 The patient, who had been placed on daily folic acid (5 mg/day), continued to require an average of 2.5 blood units per year until, at the age of 25, he developed obstructive jaundice due to gallstones