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10.1186/s12974-020-1721-z 181

Experimental literature describes BPC-157 as a relatively stable short peptide compared with many endogenous regulatory peptides

[DOI] [PMC free article] [PubMed] [Google Scholar] Lloyd E, Somera-Molina K, Van Eldik LJ, Watterson DM, Wainwright MS (2008) Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury

These intermediary degradation products are then respectively further broken down into glutathione single amino acid constituents by (i) a member of the M17 family of metallopeptidases, the Leu aminopeptidase 1 (EC 3.4.13.18) encoded by AtLAP1 in Arabidopsis [138], and (ii) by the ATP-dependent 5-oxoprolinase (5-OPase, EC 3.5.2.9) [135] (Figure 2)