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Formation of a vitamin C conjugate of acrolein and its paraoxonase-mediated conversion into 5,6,7,8-tetrahydroxy-4-oxooctanal

Moreover, consistent with the inhibition of constitutive STAT3 functions, treatment with the R001 attenuated the expression of STAT3 downstream target genes, including c-Myc, Mcl-1, Bcl-2, Bcl-xL, and vascular endothelial growth factor (VEGF) in MDA-MB-468 and MDA-MB-231 cells (Fig

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Furthermore, it is important to form the DHA-TF adducts in serum-free medium to avoid the formation of DHA-BSA ( Figure S1B ), which confirms that DHA interacts with TF at neutral pH (35)