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In this manuscript, we propose that an integrative neurogenomics workflowcombining multi-omic phenotypeoriented whole-exome sequencing, biologically-oriented common variant burden profiling, biochemical markers, functional metagenomic data, and multidisciplinary clinical interpretationcan generate testable, personalized diagnostic and therapeutic hypotheses in neurodegenerative disorders
The brain is metabolically expensive neurons consume a disproportionate share of the body's ATP
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In this case, heterogeneity was categorized as low, moderate, or high for I 2 values of 25%, 50%, and 75%, respectively, and the chi-square test was considered statistically significant with a P value of T mutation in 5,10-methylenetetrahydrofolate reductase and colorectal cancer risk
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