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Fillman SG, Cloonan N, Miller LC, Weickert CS

185 Pyruvate kinase deficiency has a protective effect against replication of the malarial parasite in human erythrocytes.13,58 This protective effect may be related to reduced ATP levels in PK-deficient red blood cells

Critical safety considerations for laboratory use include potential immunogenicity concernswith peptide therapeutics commonly showing injection site reactions (20-40% with subcutaneous administration) and possible antidrug antibody formationalong with theoretical concerns that pro-angiogenic properties could potentially influence experimental tumor models, requiring appropriate controls in oncology-related research

Salzman, who calls it the centerpiece of biology. Its the fuel behind three big jobs that keep you ticking: energy, DNA protection, and oxidative defense

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