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In DIO rats, RM-718 demonstrated comparable activity to setmelanotide on weight and food intake reduction in a 14-day study ( Currently, RM-718 is being tested in a four-part phase I clinical trial in participants with general obesity, HO, and Prader-Willi Syndrome (NCT06239116)

127 YangX.LiF.MaJ.LiuY.WangX.WangR.et al (2021)

A single Melanotan-1 injection binds melanocortin receptors on melanocytes, triggering intracellular cAMP elevation and subsequent MITF (microphthalmia-associated transcription factor) upregulation

To test if CrAT is necessary for the carnitine-mediated shuttling of acetyl-units out of the mitochondria, we generated ACLY KO/CrAT KO cells (Supplemental Figure 7G, H)