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It functions as a direct tyrosinase inhibitor that binds to the copper ions essential for enzyme activity, effectively blocking melanin synthesis while also demonstrating antioxidant properties that provide additional skin protection benefits beyond simple pigmentation reduction

5-FU administration contributes to oxidative stress, leading to peroxidation, oxidation, and cross-linking of membrane lipids, proteins, and cellular thiols, leading to the formation of malondialdehyde, ROS, hydroxyl radicals, superoxide anions, and so forth

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For patients who will not inject, sublingual is better than nothing

PMID: 38874176 Int J Med SciRIP1-dependent Apoptosis and Differentiation Regulated by Skp2 and Akt/GSK3 in Acute Myeloid Leukemia