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J Neurosci 28:50075017

thus lack of this enzyme makes them highly susceptible to ROS-induced damage

Interestingly, a further indication that lipid peroxidation may be linked to aging is provided by studies in Drosophila [98]

Via the activation of TLR4/MAPK signaling in KCs (87), low SAMe levels induce the expression of transforming growth factor- (TGF-) in KCs (89), which in turn leads to the activation of HSCs