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Vitamin B12 is necessary for patients with a low serum level of vitamin B12 because they take particular medications or because they suffer from pernicious anemia, gastrointestinal or autoimmune disorders, or alcoholism

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More significant structural changes, such as improved firmness and smoother texture, typically become visible after two to three months of consistent nightly use

(2006) Hematological response to short-term oral cyanocobalamin therapy for the treatment of cobalamin deficiencies in elderly patients