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The PI3K/AKT/mTOR signaling pathway is one of the important mechanisms of tamoxifen resistance, and HER2 activates PI3K as a member of the EGFR family ( p -AKT is associated with a worse prognosis, and inhibiting the expression of AKT is beneficial for sensitizing drug-resistant cells (Zhu et al., 2018), which makes the PI3K/AKT pathway particularly important in the treatment of breast cancer
doi: 10.1093/ije/dyw319 27
[DOI] [PubMed] [Google Scholar] 93.Poels M.M.F., Ikram M.A., Vernooij M.W., Krestin G.P., Hofman A., Niessen W.J., van der Lugt A., Breteler M.M.B
