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A recent study discovered a correlation between high blood TSH levels and cholelithiasis in males but not females

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Esculetin reduced lesion extension, and diarrhea incidence, and restored GSH levels in acute colitis, whereas 4-methyl-esculetin seemed to exert a superior efficacy, also inhibiting MPO and alkaline phosphatase activities, beneficial in acute and relapse colitis models likely due to its methyl group at C-4

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Because it is pure protein, it behaves predictably