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L Pharmazie 1975
doi: 10.1016/S0140-6736(18)31785-9
Induction of ferroptosis can synergize with immune checkpoint inhibitors (ICIs) by reshaping the TME towards a more immunogenic state, overcoming resistance mechanisms (45)
This action releases the active glutathione directly into the intracellular space
Another study demonstrated that the NO/cGMP pathway was inhibited in the DM-associated ED rats, accompanied by the occurrence of autophagy and apoptosis, as well as the high expression of mammalian target of rapamycin in the penis [93]
