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Those patients with immune-related disorders such as HIV or are allergic to lidocaine are also not candidates

This compound not only inhibited SARM1s NADase activity effectively but also exhibited a favorable safety profile, making it a strong candidate for further development 233

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When B12 pathways are disrupted by chronic illness, the methylation cycle stalls, leading to a dangerous accumulation of homocysteine in the bloodstream

[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Clinical and laboratory features and response to treatment in patients presenting with vitamin B12 deficiency-related neurological syndromes