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The rate-limiting enzyme of de novo serine synthesis is 3-phosphoglycerate dehydrogenase (PHGDH), of which the copy number is reported to be significantly increased in melanoma to ensure tumor cell survival and proliferation under low physiological serine concentrations
Conjugate a short PEGsulfonate to the phenyl sulfonamide, increasing polarity and limiting bloodbrain barrier penetration, reducing headache
sc-7196), mouse anti-human MDR1 (1:300
Wu X, George RL, Huang W, Wang H, Conway SJ, Leibach FH et al
