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Deficiency, common in regions with selenium-poor soil, slashes GPx expression, particularly GPx1, leading to heightened oxidative stress

Notably, loss-of-function mutations in ABCG2 (e.g., Q141K) impair intestinal urate excretion, thereby significantly increasing the risk of gout (Kawaguchi et al., 2021

After my last diagnosis, I started taking B-12 and D-3 pills but felt little difference in my everyday health

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High-dose B12, given through injections, may help ease these symptoms