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Then, -GC is combined with Gly through a typical -linkage by the enzyme GSH synthetase (GS), which also requires ATP and Mg 2+ as co-substrates, ultimately resulting in the formation of GSH (Figure 2A) [11]

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H 2 S production may be involved in vascular smooth muscle cell relaxation through regulating the opening/closing of potassium channels and/or enhancing NO-dependent signaling pathway (reviewed in 53)