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Is it caused by poor skin quality (crepey skin with lots of tiny wrinkles)

Itching is another possible symptom of B12 deficiency

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Most patients begin noticing changes by weeks three to four: improved sleep, faster recovery, and a general sense of steadiness

Oxidative stress happens through several ways: Homocysteine goes through oxidation and auto-oxidation [18] Low folate reduces antioxidant enzyme activities, including superoxide dismutase and glutathione peroxidase [18] These changes create an environment that hurts cell function [18] Folate supplements can work as antioxidants by lowering homocysteine levels and boosting intraerythrocyte glutathione directly [19]