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10.1371/journal.pone.0024585 172

Macrophages exhibit a heterogeneous and plastic phenotype, capable of polarizing into the pro-inflammatory M1 or the reparative and anti-inflammatory M2 phenotypes

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[DOI] [PubMed] [Google Scholar] 44.Porfire AS, Leucua SE, Kiss B, Loghin F, Prvu AE

Notably, certain drugs, such as barbiturates and ethanol, can potentiate inhibition by increasing chloride inward flow or directly opening chloride channels, which can lead to fatal drug overdose [39] (Fig