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Regular consumption can lead to caffeine dependence, with withdrawal symptoms such as headaches, fatigue, and irritability
Strengths of the current study include the large sample size, the detailed clinical assessment of depression and related characteristics, and the availability of the same data collected from participants still involved after 6 years of follow-up (totaling over 4,000 observations), which allowed further testing of the consistency of the detected associations

While PGC-1 agonists suppress NF-B via NADPH synthesis [198] (Fig

[154], the cardioprotective effect of carnitine was demonstrated in a rat model of myocardial infarction

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